CI-Dextran mix
This is a dextran mixture containing at least 13% cyclic oligosaccharide, “CI” (cyclodextran) by weight, a functional ingredient that inhibits the formation of dental plaque.
This new oral care product is manufactured exclusively by Nissin Sugar.
Standards
| CI7 to 12 | Minimum 13% |
|---|---|
| General | Not more than 3,000/g |
| Mold | Not more than 500/g |
| Yeast | Not more than 500/g |
| Coliform bacteria | Negative |
Overview
| Contents | 500 g |
|---|---|
| Storage instructions | Store at room temperature away from direct sunlight, high temperatures, and high humidity. |
| Expiraton date | Three years from date of manufacture |
Safety
| Naturally occurring ingredient found in brown sugar Has undergone a range of safety tests. |
CI is an abbreviation for cyclodextran, a cyclic oligosaccharide consisting of glucose units linked together in rings. Its major characteristic is its capacity to inhibit the formation of dental plaque.
Despite similarities to cyclodextrin, CI differs in its glucose bonding mode.
| CI (cyclodextran) |
CD (cyclodextrin) |
|
|---|---|---|
| Component | Glucose | Glucose |
| Bonding mode | α-1,6 bond | α-1,4 bond |
| Dental plaque formation inhibiting effect | Yes | No |
 |
 |
Dental plaque is an aggregate consisting of bacteria such as caries and periodontal disease bacteria, together with polysaccharides (glucans). Caries bacteria produce insoluble glucan from sugar through the action of an enzyme called “GTF,” which forms dental plaque. Tooth decay occurs due to the acid produced by caries bacteria within the dental plaque, which dissolves the tooth surface.
The presence of dental plaque also encourages the growth of periodontal disease bacteria, which can cause bad breath and virus infection.
The best way to resolve oral care issues is to prevent dental plaque from forming.
* GTF: Insoluble glucan synthase
The unique structure of CI blocks the action of GTF. While substances like xylitol are described as sugars not readily usable by caries bacteria, CI actually blocks the action of caries bacteria, preventing caries bacteria from making use of sugar. Thus, it is effective in blocking the actions of caries bacteria even when consumed with sugar that these bacteria can use.
- 168th Annual Meeting of Japanese Association for Dental Research (November 7-8, 2020) “Inhibitory Effect of Cyclodextran on Glucosyltransferase B in Streptococcus mutans”
- 259th Japan Pediatric Society Convention (June 7-20, 2021) “Study of cyclodextran’s inhibition of enzyme activity in Streptococcus mutans”
- 359th Japan Pediatric Society Convention (June 7-20, 2021) “Study into the biofilm destruction effects of cyclodextran”
- 471st Japanese Society of Applied Glycoscience (August 31 - September 2, 2022) “Study of solubilization methods for poorly soluble substances using CI-Dextran mix, a product containing cyclic isomaltooligosaccharides”
- General foods and confectionary
Effective even in foods containing sugar. - Health foods and supplementsy
Effective even in small quantities. - Dental products
Can be used in toiletry products
INCI name: Cyclized Leuconostoc Ferment Filtrate - Pet products
Other functions include the potential exhibition of inclusion effects.
(masking effects, solubilization, stabilization, improved bioavailability)
Tasteless and odorless
Highly stable and resistant to heat, acids, and alkalis
Highly soluble in equivalent volumes of water
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